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Both studies were performed by a team led by Aneel Aggarwal, PhD, Professor of Pharmacological Sciences and Oncological Sciences at the Icahn School of Medicine at Mount Sinai, and which also included Rinku Jain, PhD, Assistant Professor of Pharmacological Sciences, and Adolfo Garcia-Sastre, PhD, Professor of Microbiology and Director of the Global Health & Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai, as well as their former colleague Javier Colomo, PhD. Determining the three-dimensional structures of a virus and its enzymes is a crucial prerequisite for structure-based drug discovery, said Dr. Aggarwal. Once we know the precise shape of these entities, we can work on inhibiting them. Drug development within the field of structural biology relies on high-resolution three-dimensional structures coupled with computational and medicinal chemistry. While the same enzymes exist in other flaviviruses (such as Dengue and West Nile), the exact shape of the enzymes is different in each virus. In these studies, Dr. Aggarwal and his team identified the shape of the enzymes in a short amount of time and immediately made their results available to researchers throughout the world working to find an effective treatment for Zika virus. useful siteThe next step would be to develop compounds to inhibit these enzymes actions by physically blocking them, interfering with the reproduction of the virus, said Dr. Aggarwal.
The Netherlands international struck his first top-flight goal since September 2015 before two more in the final eight minutes secured a fourth league win in a row for the home side and ensure that David Moyes’ return to Old Trafford was a disappointing one. United, who were without captain Wayne Rooney due to a knock sustained in training, have begun to build some momentum under Jose Mourinho,but were sluggish and short on inspiration in a tepid opening half-hour. Indeed, it was Victor Anichebe who missed the best chance of the half when he mishit a shot from only six yards out, before Blind at last broke the deadlock with an accurate finish. Jordan Pickford produced a handful of good saves to deny United as some nervousness crept into the home fans in the closing stages, with memories of late goals conceded against Stoke City and Arsenal still fresh in their minds. Butthe hosts made sure of the win eight minutes from time as Ibrahimovic finally got the better of the Sunderland goalkeeper from close range. Mkhitaryan’s sublime finish capped the victory that moves United to within three points of fourth-placed Manchester City, who face Hull City in the late game on Monday, while Sunderland – who got a consolation through a fantastic Fabio Borini strike – remain in 18th position in the table. Patrick van Aanholt brought a good save from David de Gea with a well-struck free-kick as Sunderland began to grow in confidence after some early United dominance, though the home side felt they should have had a penalty when Juan Mata was shouldered to the ground by Lamine Kone. Paul Pogba’s curling effort from the edge of the area was deflected onto the outside of Pickford’s left-hand post, but Sunderland wasted their best chance of the half when Anichebe scuffed a shot against the leg of De Gea after a defensive mix-up left him in space only six yards from goal. Pogba flashed another dipping shot over the crossbar, but United found the breakthrough six minutes before half-time through an unlikely source. Ibrahimovic collected the ball to the right of the Sunderland area and slid a pass into the run of Blind, who drilled a fine left-footed strike across Pickford’s goal and into the bottom corner. It could have been worse for the visitors before the break but for Pickford, who reacted well to keep out Pogba’s clever effort following a good United move before he dived low to his right to parry Mata’s free-kick.
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