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Shaywitz, MD, PhD, chief medical officer of DNAnexus. Its thrilling to see what can be accomplished when audacious champions commit their organizations to ambitious goals, and were privileged at DNAnexus to provide the platform capabilities that enable the vision to be implemented, science to be advanced, and improved care to be delivered. Next-generation sequencing technologies have reduced the cost and increased the speed of DNA sequencing to the point where genome informatics is often the bottleneck. To address this issue, the DNAnexus translational medicine platform allows the RGC to analyze a massive volume of raw sequencing data rapidly and economically, enabling the processing of samples from more than 1,000 patients per week and the sharing of data easily and safely with collaborators such as GHS. The platform also provides a secure environment where genetic data can be combined with de-identified clinical data, paving the way for novel scientific insights. These studies are a powerful example of how the DNAnexus platform is employed as the proven option at scale by organizations and consortia globally to integrate data, enable collaboration, and accelerate discovery, said Richard Daly, chief executive officer of DNAnexus. Genomic data from these patients, all members of the Geisinger MyCode Community Health Initiative, have been linked to corresponding de-identified electronic health records, enabling the discovery of clinical associations supporting new and existing therapeutic targets. To date, 126,000 GHS patients have consented to participate in the MyCode initiative. about job interviewOf those, 50,726 have had their exomes sequenced through the organizations collaboration with RGC and analyzed on the DNAnexus translational platform. More than 200 patients where disease-causing variants were found have had results returned to them so far. These results were verified by an independent, certified lab and the results were delivered via established medical protocols.
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